Mutating ‘More Rapidly’: The Evolution of Mpox
An orthopoxvirus similar to smallpox, Mpox has recently shown signs of accelerated mutation due to the APOBEC3 genetic signature. This mutation, identified in clade Ib infections that emerged in September 2023, is causing the virus to evolve at a faster rate than anticipated.
Dr. Miguel Paredes of Fred Hutchison Cancer Center in Seattle stated that the virus, previously known for its stability and slow mutation rate, is now mutating more rapidly due to APOBEC-driven mutations. This has led to multiple outbreaks of the virus, complicating response efforts.
While Mpox was traditionally transmitted through contact with infected animals, mutations in clade Ib and IIb have turned it into a sexually transmitted disease. The increased consumption of bushmeat and deforestation in regions like Congo has contributed to the rise in cases.
Children, pregnant women, and individuals with weakened immune systems are at higher risk of severe Mpox infections. However, diagnostic testing and access to essential supplies for tracking outbreaks remain challenging in Africa, hindering response efforts.
More research and support are urgently needed to combat the spread of Mpox in affected regions.
Source: Reuters
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